The Influence of some Anti-pyretic and Anti-inflammatory Drugs on the Activity of Lactate Dehydrogenase ; Kinetic Study.

Abstract

Abstract

   Lactate dehydrogenase (LDH) is an enzyme EC (1. 1.1.27) that functions in anaerobic glucose metabolism and glucose synthesis ^(1). LDH is present in a wide variety of organisms including plants and animals ⁽²⁾. LDH has known effectors like lactate , pyruvate, NAD⁺, NADH, pH, buffers composition, ionic strength⁽⁴⁾, fructose 1,6 bisphosphate, divalent cations such as Mn²⁺ or Co^{2+ (5)}. Proline and trimethylamine oxid (2µ) also affect the activity of LDH⁽⁶⁾. Drugs like antipyretic and anti-inflammatory were reported to affect lactate dehyydrogenase activity ^(7,8).